Due to its cleavage to ADP and inorganic phosphate, ATP releases a large amount of energy used to reduce muscle protein synthesis, urea, intermediate metabolism, etc.. Influenced ATP products occurs lowering blood pressure and relaxation of smooth muscle, improved conduction of nerve impulses in the autonomic testosterone cypionate side effects ganglia and the transfer of excitation of the vagus nerve on the heart, increases myocardial contractility. After parenteral administration, it penetrates the cell bodies which splits into adenosine and inorganic phosphate with the release of energy. In the future, the cleavage products are included in the re-synthesis of ATP. Antiarrhythmic effect is due to formed by the decay of ATP adenosine overwhelming automatism sinoatrial node and Purkinje fibers (calcium channel blockade and increased permeability for potassium ions).
Relief of paroxysmal supraventricular tachycardia (except for the flicker and / or atrial flutter).
: Hypersensitivity, acute myocardial infarction, hypotension, inflammatory lung disease.
Dosing and Administration
The drug is administered intravenously rapidly in central or large peripheral vein 3 mg for 2 seconds under the control of ECG and blood pressure; if necessary testosterone cypionate side effects after 1-2 minutes reintroduced 6 mg, in 1-2 min. 12 mg; administration is stopped at a developing atrioventricular block at any stage of administration.
are possible allergic reactions (itching, redness of the skin), nausea, facial flushing, headache, weakness; after a paroxysm of tachycardia may experience intermittent episodes of sinus bradycardia and / or atrioventricular blockade of I – III degree (ECG control).
Due to the short half-life, adverse events are rapidly disappearing. Competitive antagonists are theophylline and other methylxanthines.
Interaction with other medicinal products
Cardiac glycosides increase the risk of side effects (including arrhythmogenic action). Dipyridamole increases the effect; theophylline, caffeine and other methylxanthines – weaken.
can not be administered in large doses, simultaneously with cardiac glycosides.
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